| Identification | Back Directory | [Name]
1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one | [CAS]
882288-28-0 | [Synonyms]
AI-3
1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one
1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one
Benzo[c]thiophen-4(5H)-one, 1-chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)- | [Molecular Formula]
C11H13ClO3S2 | [MOL File]
882288-28-0.mol | [Molecular Weight]
292.8 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml). | [form ]
solid | [color ]
White | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Description]
AI-3 (882288-28-0) is an activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at Cys151 and is reactive toward additional cysteines at higher concentrations. Disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. AI-3 activates ARE in an Nrf2 and PI 3-kinase dependent manner. Cell permeable and active?in vivo. | [Uses]
AI-3 is an electrophilic, antioxidant response element (ARE) activator. AI-3 has the potential to become a valuable biological tool regarding the development of therapeutics towards oxidative stress related diseases. | [References]
1) Wang?et al. (2013),?In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway; ACS Chem. Biol.,?8?1764 |
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