| Identification | Back Directory | [Name]
6H-Purin-6-one, 3,7-dihydro-3-methyl-7-[(2E,6E,11Z)-3,7,11,15-tetramethyl-13-oxo-2,6,11-hexadecatrien-1-yl]- | [CAS]
882403-69-2 | [Synonyms]
Malonganenone A
Malonganenone E
Malonganenone-A
Malonganenone-E
6H-Purin-6-one, 3,7-dihydro-3-methyl-7-[(2E,6E,11Z)-3,7,11,15-tetramethyl-13-oxo-2,6,11-hexadecatrien-1-yl]- | [Molecular Formula]
C26H38N4O2 | [MOL File]
882403-69-2.mol | [Molecular Weight]
438.61 |
| Hazard Information | Back Directory | [Description]
Malonganenone A is a selective modulator of plasmodial Hsp70s with antimalarial activity. | [Uses]
Malonganenone A is an antimalarial marine alkaloid that disrupts the interaction between PfHsp70-x and Hsp40. Malonganenone A inhibits plasmodial and not human Hsp70 ATPase activity (Hsp40-stimulated), and hindered the aggregation suppression activity of PfHsp70-x[1]. | [References]
[1] Ingrid L Cockburn, et al. Selective modulation of plasmodial Hsp70s by small molecules with antimalarial activity. Biol Chem. 2014 Nov 1;395(11):1353-62. DOI:10.1515/hsz-2014-0138 |
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