| Identification | Back Directory | [Name]
4-DEOXYPYRIDOXINE 5-PHOSPHATE | [CAS]
883-84-1 | [Synonyms]
4-Deoxypyridoxine Phosphate
4-DEOXYPYRIDOXINE 5-PHOSPHATE
(5-hydroxy-4,6-dimethyl-3-pyridyl)methyl dihydrogen phosphate
(5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate
(5-hydroxy-4,6-dimethyl-pyridin-3-yl)methyl dihydrogen phosphate
3-Pyridinemethanol, 5-hydroxy-4,6-dimethyl-, 3-(dihydrogen phosphate) | [Molecular Formula]
C8H12NO5P | [MDL Number]
MFCD00056050 | [MOL File]
883-84-1.mol | [Molecular Weight]
233.16 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Water: soluble | [form ]
A crystalline solid | [color ]
White to off-white | [Water Solubility ]
Water: soluble |
| Hazard Information | Back Directory | [Uses]
4-Deoxypyridoxine 5'-phosphate is a Pyridoxal 5'-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5'-phosphate inhibits ornithine decarboxylase activity with a Ki of 60 μM. 4-Deoxypyridoxine 5'-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5'-phosphate (Ki of 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase[1][2][3]. | [storage]
Store at -20°C | [References]
[1] Mamoru Ohtoyo, et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. Lipids. 2016 Oct;51(10):1207-1216. DOI:10.1007/s11745-016-4187-0
[2] M J Connor, et al. Epidermal Pyridoxal 5'-phosphate Depletion, Inhibition of DNA Synthesis, and Inhibition of the Expression of Ornithine Decarboxylase Activity by the Vitamin B-6 Antagonist 4'-deoxypyridoxine. J Invest Dermatol. 1983 Aug;81(2):136-9. DOI:10.1111/1523-1747.ep12543346
[3] D L Martin, et al. Glutamate-dependent Active-Site Labeling of Brain Glutamate Decarboxylase. J Neurochem. 1990 Aug;55(2):524-32. DOI:10.1111/j.1471-4159.1990.tb04166.x |
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