ChemicalBook--->CAS DataBase List--->883046-50-2

883046-50-2

883046-50-2 Structure

883046-50-2 Structure
IdentificationBack Directory
[Name]

S14161
[CAS]

883046-50-2
[Synonyms]

S14161
SAG Analog (LowTox)
8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran
2H-1-Benzopyran, 8-ethoxy-2-(4-fluorophenyl)-3-nitro-
[Molecular Formula]

C17H14FNO4
[MDL Number]

MFCD00112055
[MOL File]

883046-50-2.mol
[Molecular Weight]

315.296
Chemical PropertiesBack Directory
[Boiling point ]

456.2±45.0 °C(Predicted)
[density ]

1.34±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: soluble
[form ]

A solid
[color ]

Yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315
[Precautionary statements ]

P264-P280-P302+P352-P321-P332+P313-P362+P364
Hazard InformationBack Directory
[Description]

D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM). S14161 induces apoptosis in myeloma and leukemia cell lines (IC50s < 10 μM) but is less toxic to normal hematopoietic cells (IC20 > 25 μM). In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day.
[Uses]

D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM). S14161 induces apoptosis in myeloma and leukemia cell lines (IC50s < 10 μM) but is less toxic to normal hematopoietic cells (IC20 > 25 μM). In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day.[Cayman Chemical]
[Uses]

S14161 is a small-molecule inhibitor of D-cyclin transactivation that displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.
[storage]

Store at -20°C
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