| Identification | Back Directory | [Name]
S14161 | [CAS]
883046-50-2 | [Synonyms]
S14161
SAG Analog (LowTox)
8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran
2H-1-Benzopyran, 8-ethoxy-2-(4-fluorophenyl)-3-nitro- | [Molecular Formula]
C17H14FNO4 | [MDL Number]
MFCD00112055 | [MOL File]
883046-50-2.mol | [Molecular Weight]
315.296 |
| Chemical Properties | Back Directory | [Boiling point ]
456.2±45.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble | [form ]
A solid | [color ]
Yellow |
| Hazard Information | Back Directory | [Description]
D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM). S14161 induces apoptosis in myeloma and leukemia cell lines (IC50s < 10 μM) but is less toxic to normal hematopoietic cells (IC20 > 25 μM). In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day. | [Uses]
D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM). S14161 induces apoptosis in myeloma and leukemia cell lines (IC50s < 10 μM) but is less toxic to normal hematopoietic cells (IC20 > 25 μM). In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day.[Cayman Chemical] | [Uses]
S14161 is a small-molecule inhibitor of D-cyclin transactivation that displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. | [storage]
Store at -20°C | [References]
[1] XINLIANG MAO. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.[J]. Blood, 2011: 1986-1997. DOI: 10.1182/blood-2010-05-284810 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
NE Scientific
|
| Tel: |
+1 (617) 651-6662 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19253/0_EN.htm |
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