| Identification | Back Directory | [Name]
3,6,9,12-Tetraoxatetradecanoic acid, 13,13-dimethyl-11-oxo- | [CAS]
883564-93-0 | [Synonyms]
HOOCCH2O-PEG2-CH2COOtBu
3,6,9,12-Tetraoxatetradecanoic acid, 13,13-dimethyl-11-oxo-
13,13-Dimethyl-11-oxo-3,6,9,12-tetraoxatetradecan-1-oic acid | [Molecular Formula]
C12H22O7 | [MOL File]
883564-93-0.mol | [Molecular Weight]
278.3 |
| Hazard Information | Back Directory | [Description]
t-butyl acetate-PEG2-CH2COOH is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
t-Butyl acetate-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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