| Identification | Back Directory | [Name]
(D-PEN2,PEN5)-ENKEPHALIN | [CAS]
88373-72-2 | [Synonyms]
DPLPE
TYR-D-PEN-GLY-PHE-PEN
(D-PEN2,PEN5)-ENKEPHALIN
[D-PEN2,L-PEN5]-ENKEPHALIN
H-TYR-D-PEN-GLY-PHE-PEN-OH
L-Tyr-D-Pen-Glu-L-Phe-L-Pen-OH
H-Tyr-D-Pen-Gly-Phe-Pen-OH (Disulfide bond)
Tyr-D-Pen-Gly-Phe-D-Pen (Disulfide bridge D-Pen2-D-Pen5)
1,2-Dithia-5,8,11-triazacyclotetradecane,cyclic peptide deriv.
L-Valine, L-tyrosyl-3-mercapto-D-valylglycyl-L-phenylalanyl-3-mercapto-, cyclic (2→5)-disulfide | [Molecular Formula]
C30H39N5O7S2 | [MDL Number]
MFCD00076431 | [MOL File]
88373-72-2.mol | [Molecular Weight]
645.79 |
| Hazard Information | Back Directory | [Uses]
[DPen2, Pen5] Enkephalin is a δ-opioid receptor selective analog of [Leu5]-Enkephalin.html" class="link-product" target="_blank">[Leu5]-Enkephalin (HY-P0288)[1]. | [in vivo]
[DPen2, Pen5] Enkephalin (0-3.32 μg/kg, IP) impairs acquisition of an automated jump-up avoidance response in rats and acquisition of a one-way active avoidance response in mice[1]. | Animal Model: | Male Sprague-Dawley rats (260-280 g)[1] | | Dosage: | 0, 1.16, 11.6 μg/kg | | Administration: | IP, administered on day 2 prior to presentation of eight training trials, on subsequent one-way avoidance responding. | | Result: | Produced a significant impairment of avoidance performance at 1.16 ug/kg, while the 11.6 ug/kg dose was without significant effect. |
| Animal Model: | Male Sprague-Dawley rats (260-280 g)[1] | | Dosage: | 0, 0.332, 3.32 μg/kg | | Administration: | IP, administered on day 1 immediately after presentation of two escape-only trials, on subsequent day 2 one-way avoidance responding in the second experiment | | Result: | Produced a significant enhancement of avoidance performance at 0.332 ug/kg, while the 3.32 ug/kg dose was without significant effect. |
| [IC 50]
δ Opioid Receptor/DOR | [References]
[1] Martinez JL Jr, et al. D-Pen2-[D-Pen5]enkephalin impairs acquisition and enhances retention of a one-way active avoidance response in rats. Peptides. 1992 Sep-Oct;13(5):885-9. DOI:10.1016/0196-9781(92)90045-5 |
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