| Identification | Back Directory | [Name]
N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride | [CAS]
883976-12-3 | [Synonyms]
M8-B
M8-B hydrochloride
M8-B hydrochloride >=98% (HPLC)
N-(2-Aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride
N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
2-Thiophenecarboxamide, N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-, monohydrochloride | [Molecular Formula]
C22H25ClN2O3S | [MDL Number]
MFCD27978374 | [MOL File]
883976-12-3.mol | [Molecular Weight]
432.964 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble2mg/mL, clear (warmed) | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: 2mg/mL, clear (warmed) |
| Hazard Information | Back Directory | [Description]
M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin , or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively). It displays no effect at other TRP channels. M8-B decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice. | [Uses]
M8 B Hydrochloride is a channel blocker of cold receptor TRPM8. | [in vivo]
M8-B (6 mg/kg; i.v. or i.p.) decreases deep body body temperature (Tb) in rats and mouse[1]. | Animal Model: | Trpm8+/+ rats and mice[1] | | Dosage: | 6 mg/kg | | Administration: | I.v. or i.p. | | Result: | Decreased deep body temperature (T(b)) in Trpm8+/+ rats and mice, but not in Trpm8?/? mice. |
| [IC 50]
TRPM8 | [storage]
Store at +4°C | [References]
[1] M CAMILA ALMEIDA. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.[J]. Journal of Neuroscience, 2012, 32 6: 2086-2099. DOI: 10.1523/jneurosci.5606-11.2012 |
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