| Identification | Back Directory | [Name]
L-(-)-α-Methyldopa (hydrochloride) | [CAS]
884-39-9 | [Synonyms]
L-(-)-&
MK-351 hydrochloride
(-)-α-Methyldopa Hydrochloride
L-(-)-α-Methyldopa (hydrochloride)
L-(-)- Alpha -Methyldopa hydrochloride
3-hydroxy-a-methyl- L-Tyrosine hydrochloride | [Molecular Formula]
C10H14ClNO4 | [MDL Number]
MFCD28167743 | [MOL File]
884-39-9.mol | [Molecular Weight]
247.68 |
| Hazard Information | Back Directory | [Uses]
Methyldopa-d3 (hydrochloride) is deuterium labeled Methyldopa (hydrochloride). Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system[1][2]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6(5 Pt 2):II51-II56. DOI:10.1161/01.hyp.6.5_pt_2.ii51
[3] Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78(3):342-350. DOI:10.1016/0041-008x(85)90239-x |
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