| Identification | Back Directory | [Name]
1H-Benzimidazole-2-propanoic acid, 6-fluoro-α-[(2-naphthalenylcarbonyl)amino]-, (αR)- | [CAS]
884033-66-3 | [Synonyms]
AG-17724 >=98% (HPLC)
(R)-2-(2-Naphthamido)-3-(6-fluoro-1H-benzo[d]imidazol-2-yl)propanoic acid
(R)-2-(2-naphthamido)-3-(5-fluoro-1H-benzo[d]imidazol-2-yl)propanoic acid
1H-Benzimidazole-2-propanoic acid, 6-fluoro-α-[(2-naphthalenylcarbonyl)amino]-, (αR)- | [Molecular Formula]
C21H16FN3O3 | [MDL Number]
MFCD28411616 | [MOL File]
884033-66-3.mol | [Molecular Weight]
377.38 |
| Chemical Properties | Back Directory | [Boiling point ]
772.5±60.0 °C(Predicted) | [density ]
1.437±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: 20mg/mL, clear (warmed) | [form ]
powder | [pka]
3.12±0.30(Predicted) | [color ]
white to light brown | [InChI]
InChI=1/C21H16FN3O3/c22-15-7-8-16-17(10-15)24-19(23-16)11-18(21(27)28)25-20(26)14-6-5-12-3-1-2-4-13(12)9-14/h1-10,18H,11H2,(H,23,24)(H,25,26)(H,27,28)/t18-/s3 | [InChIKey]
NKMPZFCFXCJBEY-ZAWDOUAYNA-N | [SMILES]
C(C1=NC2=CC(F)=CC=C2N1)[C@H](C(=O)O)NC(C1C=CC2C=CC=CC=2C=1)=O |&1:11,r| |
| Hazard Information | Back Directory | [Uses]
PIN1 inhibitor 5 (compound 7) is a PIN1 inhibitor (Ki=0.08 μM) ,which can be used in cancer research[1]. | [Biological Activity]
AG-17724 is a potent peptidyl-prolyl isomerase (PPIase) Pin1 inhibitor. | [References]
[1] Chuangxing Guo, et al. Structure-based design of novel human Pin1 inhibitors (III): optimizing affinity beyond the phosphate recognition pocket. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4187-91. DOI:10.1016/j.bmcl.2014.07.044 |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 19945035818 |
| Website: |
www.topule.com/ |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|