| Identification | Back Directory | [Name]
ARPHAMENINE B | [CAS]
88465-81-0 | [Synonyms]
Arpharmenine B
arphamenine B hydrochloride
monohydrochloride,(s-(r*,s*))--hydroxy
5-amino-8-guanidino-2-(4-hydroxyphenylmethyl)-4-oxooctanoicacidhydrochlorid
alpha-(3-amino-6-((aminoiminomethyl)amino)-2-oxohexyl)-4-hydroxybenzenepropa
benzenepropanoicacid,alpha-(3-amino-6-((aminoiminomethyl)amino)-2-oxohexyl)-4 | [EINECS(EC#)]
2077887226-096-6 | [Molecular Formula]
C16H24N4O3 | [MDL Number]
MFCD00135889 | [MOL File]
88465-81-0.mol | [Molecular Weight]
320.387 |
| Hazard Information | Back Directory | [Uses]
Arphamenine B is a Zn2+-dependent exopeptidase that selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates. Arphamenine B is an inhibitor of aminopeptidase B that can be isolated from bacteria. Arphamenine B enhances the immune response and is used to characterize novel proteases[1][2][3]. | [References]
[1] Foulon T, et al. Aminopeptidase B (EC 3.4.11.6). Int J Biochem Cell Biol. 1999 Jul;31(7):747-50. DOI:10.1016/s1357-2725(99)00021-7
[2] Umezawa H, et al. Arphamenines A and B, new inhibitors of aminopeptidase B, produced by bacteria. J Antibiot (Tokyo). 1983 Nov;36(11):1572-5. DOI:10.7164/antibiotics.36.1572
[3] Kubo H, et al. Involvement of sperm proteases in the binding of sperm to the vitelline envelope in Xenopus laevis. Zoolog Sci. 2008 Jan;25(1):80-7. DOI:10.2108/zsj.25.80 |
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