| Identification | Back Directory | [Name]
FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID | [CAS]
884880-39-1 | [Synonyms]
(R)-Fmoc-b,b-dimethyl-serine
(R)-Fmoc-β-hydroxy-valine≥ 99% (HPLC)
FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
(R)-N-Fmoc-2-amino-3-hydroxy-3-methylbutanoic acid
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-hydroxy-D-valine
D-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-hydroxy-
(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-hydroxy-3-methylbutanoic acid | [Molecular Formula]
C20H21NO5 | [MDL Number]
MFCD02682577 | [MOL File]
884880-39-1.mol | [Molecular Weight]
355.38 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Synthesis]
GENERAL STEPS: (R)-N-Fmoc-2-amino-3-hydroxy-3-methylbutanoic acid was synthesized in the following steps: first, (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid was stripped of the Boc protecting group in a 1:1 trifluoroacetic acid/dichloromethane solution. Subsequently, the Fmoc protection reaction was carried out using 9-fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu) and sodium bicarbonate (NaHCO3) in aqueous acetone solution. After completion of the reaction, the product was purified by silica gel column chromatography (eluent ratio of 1:1:98 methanol/acetic acid/chloroform). Finally, the purified product was freeze-dried from aqueous acetonitrile solution to afford the target compound in 78% yield. | [References]
[1] Patent: US2009/48161, 2009, A1. Location in patent: Page/Page column 40 |
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