| Identification | Back Directory | [Name]
3-IODOINDAZOLE -5-CARBOXYLIC ACID | [CAS]
885521-46-0 | [Synonyms]
3-Iodoindazole-5-carboxyl...
3-IODOINDAZOLE -5-CARBOXYLIC ACID
3-iodo-2H-indazole-5-carboxylic acid
3-Iodo-5-(1H)indazole carbocylic acid
1H-Indazole-5-carboxylic acid, 3-iodo- | [Molecular Formula]
C8H5IN2O2 | [MDL Number]
MFCD07781585 | [MOL File]
885521-46-0.mol | [Molecular Weight]
288.04 |
| Chemical Properties | Back Directory | [Boiling point ]
512.1±30.0 °C(Predicted) | [density ]
2.220±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [pka]
3.86±0.30(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-iodo-5-(1H)indazolecarboxylic acid from indazole-5-carboxylic acid hydrochloride: 1H-indazole-5-carboxylic acid (200 mg, 1.23 mmol), N,N-dimethylformamide (3 mL), potassium hydroxide (138 mg, 2.46 mmol), and iodine (470 mg, 1.85 mmol) were added to a 25 mL round bottomed flask. The reaction mixture was stirred at 25°C for 3 hours. After the reaction was completed, the reaction was quenched by adding 10 mL of Na2S2O3 solution. The pH of the reaction solution was adjusted with 10% hydrochloric acid solution to 6. The resulting solid was collected by filtration. Finally 300 mg (84% yield) of 3-iodo-1H-indazole-5-carboxylic acid was obtained as a white solid. | [References]
[1] Patent: WO2016/26549, 2016, A1. Location in patent: Page/Page column 91 |
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ZEROSCHEM.CO.,LTD.
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http://www.zeroschem.com |
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