| Identification | Back Directory | [Name]
4-Cyano-N-[4-(4-methyl-1-piperazinyl)-2-(4-methyl-1-piperidinyl)phenyl]-1H-pyrrole-2-carboxamide | [CAS]
885704-21-2 | [Synonyms]
C-FMS-IN-3
c-FMS-IN-8
CID 11654378
c-FMS inhibitor
4-cyano-N-[4-(4-methyl-1-piperazinyl)-2-(4-methyl-1-piperidinyl)phenyl]-
4-Cyano-N-[4-(4-methyl-1-piperazinyl)-2-(4-methyl-1-piperidinyl)phenyl]-1H-pyrrole-2-carboxamide
1H-Pyrrole-2-carboxaMide, 4-cyano-N-[4-(4-Methyl-1-piperazinyl)-2-(4-Methyl-1-piperidinyl)phenyl]-
c-FMS-IN-8
(1H-Pyrrole-2-carboxamide, 4-cyano-N-[4-(4-methyl-1-piperazinyl)-2-(4-methyl-1-piperidinyl)phenyl]-) | [Molecular Formula]
C23H30N6O | [MDL Number]
MFCD22124465 | [MOL File]
885704-21-2.mol | [Molecular Weight]
406.52 |
| Chemical Properties | Back Directory | [Boiling point ]
582.7±50.0 °C(Predicted) | [density ]
1.26 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 25 mg/mL (61.50 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | [form ]
Powder | [pka]
12.96±0.50(Predicted) | [color ]
White to gray |
| Hazard Information | Back Directory | [Uses]
c-Fms-IN-3 is a novel c-Fms kinase inhibitor with a potential as anti-inflammatory agent and antirheumatic agent. | [Definition]
ChEBI: 4-cyano-N-[4-(4-methyl-1-piperazinyl)-2-(4-methyl-1-piperidinyl)phenyl]-1H-pyrrole-2-carboxamide is an aromatic amide. | [target]
FMS kinase | [References]
[1] Meegalla, Sanath K.; Wall, Mark J.; Chen, Jinsheng et al. Structure-based optimization of a potent class of arylamide FMS inhibitors. Bioorganic & Medicinal Chemistry Letters (2008), 18(12), 3632-3637. DOI:10.1016/j.bmcl.2008.04.059
[2] Illig, Carl R.; Chen, Jinsheng; Wall, Mark J. et al. Discovery of novel FMS kinase inhibitors as anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters (2008), 18(5), 1642-1648. DOI:10.1016/j.bmcl.2008.01.059 |
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