| Chemical Properties | Back Directory | [Boiling point ]
545.9±40.0 °C(Predicted) | [density ]
1.13±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
5.88±0.11(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
VA012 (compound 11) is a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. VA012 reduces food intake and body weight gain without causing CNS-related malaise during subchronic administration. VA012 can be utilized in obesity research[1]. | [References]
[1] García-Cárceles J, et al. A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity. J Med Chem. 2017 Dec 14;60(23):9575-9584. DOI:10.1021/acs.jmedchem.7b00994 |
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