| Identification | Back Directory | [Name]
Acetamide, 2-bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- | [CAS]
886212-98-2 | [Synonyms]
Acetamide, 2-bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- | [Molecular Formula]
C20H40BrNO3 | [MOL File]
886212-98-2.mol | [Molecular Weight]
422.44 |
| Chemical Properties | Back Directory | [Melting point ]
129-131 °C(Solv: hexane (110-54-3); acetone (67-64-1)) | [Boiling point ]
569.0±50.0 °C(Predicted) | [density ]
1.130±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Chloroform: soluble | [form ]
A solid | [pka]
12?+-.0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
SABRAC is a biochemical reagent. | [Biological Activity]
SABRAC is an inhibitor of acid ceramidase (IC50 = 52 nM).1 It is selective for acid ceramidase over neutral ceramidase and the cysteine protease papain at 3 μM. SABRAC inhibits acid ceramidase in PC3 MC metastatic prostate cancer cells (IC50 = <1 μM), as well as induces accumulation of ceramides in the same cells. It completely inhibits anchorage-independent colony formation but does not induce cytotoxicity in PC3 MC cells when used at a concentration of 5 μM. | [storage]
-20°C | [References]
1.Camacho, L., Meca-Cortés, O., Abad, J.L., et al.Acid ceramidase as a therapeutic target in metastatic prostate cancerJ. Lipid Res.54(5)1207-1220(2013)
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