| Identification | Back Directory | [Name]
5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID | [CAS]
886365-02-2 | [Synonyms]
5-broMo-4-Methylpicolinic acid
5-BroMo-2-carboxy-4-Methylpyridine
5-bromo-4-methylpyridin-2-carboxylic acid
5-bromo-4-methyl-2-Pyridinecarboxylic acid
2-carboxylic acid-4-methyl-5-bromopyridine
5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID
2-Pyridinecarboxylic acid, 5-bromo-4-methyl-
5-Bromo-4-methylpicolinic acid, 5-Bromo-2-carboxy-4-methylpyridine | [Molecular Formula]
C7H6BrNO2 | [MDL Number]
MFCD07375100 | [MOL File]
886365-02-2.mol | [Molecular Weight]
216.03 |
| Chemical Properties | Back Directory | [Boiling point ]
335.0±42.0 °C(Predicted) | [density ]
1.692±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
3.48±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
5-Bromo-4-methyl-2-vinylpyridine (600 mg, 3 mmol) was used as raw material and dissolved in a solvent mixture of acetone-water (1:1, 54 mL). Subsequently, potassium permanganate (KMnO4, 957 mg, 6 mmol) was added to this solution. The reaction mixture was stirred at room temperature for 3 days. Upon completion of the reaction, the mixture was filtered to remove insoluble impurities, and the filtrate was concentrated and purified by column chromatography to give 5-bromo-4-methylpyridine-2-carboxylic acid (700 mg, 92% yield) as a white solid. | [References]
[1] Patent: US2011/71150, 2011, A1. Location in patent: Page/Page column 33-34
[2] Patent: US2013/158040, 2013, A1. Location in patent: Paragraph 0134
[3] Patent: US2013/158049, 2013, A1. Location in patent: Paragraph 0168
[4] Patent: US2013/158066, 2013, A1. Location in patent: Paragraph 0134
[5] Patent: WO2012/143329, 2012, A1 |
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