| Identification | Back Directory | [Name]
1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent | [CAS]
887144-97-0 | [Synonyms]
Togni Reagent
Togni's Reagent
1-Trifluoromethyl-3,3-dimethyl-1,2-benziodoxole
3,3-DMethyl-1-(trifluoroMethyl)-1,2-benziodoxole
3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole
3,3-Dimethyl-1-(trifluoromethyl)-1,2-benzodioxole
1,2-Benziodoxole,3,3-dimethyl-1-(trifluoromethyl)-
1,3-Dihydro-3,3-diMethyl-1-(trifluoroMethyl)-1,2-b
3,3-DiMethyl-1-(trifluoroMethyl)-1,2-benziodoxole 95%
3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, >=98%
3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole / TOGNI A
1,3-Dhydro-3,3-diMethyl-1-(trifluoroMethyl)-1,2-benziodoxole
1,3-dihydro-3,3-diMethyl-1-(trifluoroMethyl)-1,2-benziodoxole
3,3-DiMethyl-1-(trifluoroMethyl)-1,2-benziodoxole (Togni‘s reagent)
3,3-Dimethyl-1-(trifluoromethyl)-1,2-
benziodoxole (Togni's reagent I)
1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent | [Molecular Formula]
C10H10F3IO | [MDL Number]
MFCD10567056 | [MOL File]
887144-97-0.mol | [Molecular Weight]
330.08 |
| Chemical Properties | Back Directory | [Melting point ]
75-79 °C | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
powder | [color ]
white to off-white | [Stability:]
Moisture Sensitive | [InChI]
InChI=1S/C10H10F3IO/c1-9(2)7-5-3-4-6-8(7)14(15-9)10(11,12)13/h3-6H,1-2H3 | [InChIKey]
HVAPLSNCVYXFDQ-UHFFFAOYSA-N | [SMILES]
I1(C(F)(F)F)C2=CC=CC=C2C(C)(C)O1 |
| Hazard Information | Back Directory | [Chemical Properties]
White to light yellow solid | [Uses]
Mild, electrophilic, hypervalent iodine CF3 reagent effective for the trifluoromethylation of a wide range of substrates. | [reaction suitability]
reaction type: C-C Bond Formation |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26-36/37 | [RIDADR ]
1325 | [WGK Germany ]
3 | [TSCA ]
No | [HazardClass ]
4.1 | [PackingGroup ]
Ⅲ | [HS Code ]
29349990 | [Storage Class]
4.1B - Flammable solid hazardous materials | [Hazard Classifications]
Eye Irrit. 2
Flam. Sol. 2
Skin Irrit. 2
STOT SE 3 |
| Questions And Answer | Back Directory | [Description]
1,3-dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole is in the form of colorless, white solid. It is soluble in all common organic solvents. It is used as effective and very versatile reagent for trifluoromethylation reactions of a variety of compounds including secondary and primary aryland alkylphospines, phenols, peptides containing cysteine residues by SPPS and electrophilic S-trifluoromethylation, arenes and N-heterocycles, and electrophilic N-trifluoromethylation of arozoles.
| [Reference]
J. Charpentier, N. Früh, A. Togni, Electrophilic Trifluoromethylation by use of hypervalent iodine reagents, Chemical Reviews, 2015, vol. 115, pp. 650-682
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