| Identification | Back Directory | [Name]
2-[3,5-DICHLOROPHENYL]PYRROLIDINE | [CAS]
887344-13-0 | [Synonyms]
2-[3,5-DICHLOROPHENYL]PYRROLIDINE
Pyrrolidine, 2-(3,5-dichlorophenyl)-
2-(3,5-Dichlorophenyl)tetrahydropyrrole, 1,3-Dichloro-5-(pyrrolidin-2-yl)benzene | [Molecular Formula]
C10H11Cl2N | [MDL Number]
MFCD02684093 | [MOL File]
887344-13-0.mol | [Molecular Weight]
216.11 |
| Chemical Properties | Back Directory | [density ]
1.250 | [form ]
Liquid | [InChI]
InChI=1S/C10H11Cl2N/c11-8-4-7(5-9(12)6-8)10-2-1-3-13-10/h4-6,10,13H,1-3H2 | [InChIKey]
RGJUGOHYPAYSDI-UHFFFAOYSA-N | [SMILES]
N1CCCC1C1=CC(Cl)=CC(Cl)=C1 |
| Hazard Information | Back Directory | [Uses]
Used as an intermediate for organic synthesis. | [Hazard]
H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H318 (50%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] | [Biological Activity]
2-(3,5-Dichlorophenyl)Pyrrolidine has been shown to act as a dopamine transporter inhibitor, which means that it blocks the reuptake of dopamine in the brain and increases its concentration in the synaptic cleft. This mechanism of action is similar to that of cocaine and other psychostimulants, and may contribute to the compound's bioactivity and potency. The compound has been shown to increase the release of dopamine and other neurotransmitters in the brain, which can lead to euphoria, increased energy, and improved cognitive function. However, chronic use of dopamine transporter inhibitors has been associated with neurotoxicity, addiction, and other adverse effects.
| [Synthesis]
2-(3,5-Dichlorophenyl)Pyrrolidine is prepared by reacting1-Bromo-3,5-dichlorobenzene with 1,1-Dimethylethyl 2-oxo-1-pyrrolidinecarboxylate:
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