| Identification | Back Directory | [Name]
Biotin-SLC-NHS | [CAS]
887628-40-2 | [Synonyms]
CAS_887628-40-2
Biotin-C10-NHS Ester
(+)-Biotin-SLC-NHS Ester
Undecanoic acid, 11-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C25H40N4O6S | [MOL File]
887628-40-2.mol | [Molecular Weight]
524.67 |
| Hazard Information | Back Directory | [Uses]
Biotin-C10-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [Biological Activity]
Biotin-C10-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
Alkyl/ether | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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