| Hazard Information | Back Directory | [Description]
YM-355179 is a novel, selective, and orally available antagonist for CC chemokine receptor 3. | [Uses]
YM-355179 fumarate is a newly synthesized selective CCR3 antagonist with the potential to inhibit eosinophil-related allergic inflammatory diseases. YM-355179 can effectively inhibit the binding of CCL11 and CCL5 to CCR3-expressing cells, with IC50 values of 7.6 nM and 24 nM respectively. In functional experiments, YM-355179 can inhibit CCL11-induced intracellular Ca(2+) influx, chemotaxis and eosinophil degranulation, IC50 The values are 8.0 nM, 24 nM and 29 nM respectively[1]. | [References]
[1] A novel, selective, and orally available antagonist for CC chemokine receptor 3 DOI:10.1124/jpet.105.097048 |
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