| Identification | Back Directory | [Name]
OSS-128167 | [CAS]
887686-02-4 | [Synonyms]
OSS-128167
SIRT6-IN-1
OSS-128167(SIRT6-IN-1)
OSS-128167;OSS 128167;OSS128167
Benzoic acid, 5-[[3-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy- | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C19H14N2O6 | [MDL Number]
MFCD07114226 | [MOL File]
887686-02-4.mol | [Molecular Weight]
366.32 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO (Slightly) | [form ]
Solid | [color ]
Red to Very Dark Brown | [InChI]
InChI=1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26) | [InChIKey]
HTJWLEGCECXGSQ-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C1=CC(NC(=O)C2=CC=CC(NC(C3=CC=CO3)=O)=C2)=CC=C1O |
| Hazard Information | Back Directory | [Biological Activity]
eCll penetrantpotent and selective inhibitor of SIRT6.
OSS_128167 is a cell penetrantpotent and selective inhibitor of SIRT6 (Sirtuin 6) th at exhibits anti-canceranti-inflammatoryand anti-viral properties. OSS_128167 inhibits HBV transcription and replication through upregulating peroxisome proliferator-activated receptors α (PPARα) expression. | [in vivo]
OSS_128167 (50 mg/kg; intraperitoneal injection; every 4 days; for 12 days; male HBV transgenic mice) treatment markedly suppresses the level of HBV DNA and 3.5-Kb RNA in HBV transgenic mice[2]. | Animal Model: | Male HBV transgenic mice (6-8-week-old)[2] | | Dosage: | 50 mg/kg | | Administration: | Intraperitoneal injection; every 4 days; for 12 days | | Result: | The level of HBV DNA and 3.5-Kb RNA were markedly suppressed in HBV transgenic mice.
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| [IC 50]
SIRT6: 89 μM (IC50); SIRT2: 751 μM (IC50); SIRT1: 1578 μM (IC50); HBV |
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