| Identification | Back Directory | [Name]
eckol | [CAS]
88798-74-7 | [Synonyms]
eckol
Acanthol
4-(3,5-Dihydroxyphenoxy)dibenzo-p-dioxin-1,3,6,8-tetrol
1-(Resorcinol-5-yloxy)-2,4,7,9-tetrahydroxydibenzo-p-dioxin
4-(3,5-Dihydroxyphenoxy)dibenzo[b,e][1,4]dioxin-1,3,6,8-tetrol
Dibenzo[b,e][1,4]dioxin-1,3,6,8-tetrol, 4-(3,5-dihydroxyphenoxy)- | [Molecular Formula]
C18H12O9 | [MDL Number]
MFCD11046406 | [MOL File]
88798-74-7.mol | [Molecular Weight]
372.28 |
| Chemical Properties | Back Directory | [Melting point ]
243-244 °C | [Boiling point ]
685.5±55.0 °C(Predicted) | [density ]
1.778±0.06 g/cm3(Predicted) | [pka]
8.06±0.20(Predicted) | [Cosmetics Ingredients Functions]
HAIR CONDITIONING
SKIN PROTECTING
SKIN CONDITIONING - MISCELLANEOUS |
| Hazard Information | Back Directory | [Uses]
Eckol is a polyphenolic compound that can be used as a potential drug candidate for treatment of Alzheimer''s disease. Eckol also enhances heme oxygenase-1 expression through activation of Nrf2/JNK pathway in HepG2 cells. | [Definition]
ChEBI: A phlorotannin that is oxanthrene-1,3,6,8-tetrol substituted by a 3,5-dihydroxyphenoxy moiety at position 4. Isolated from the marine brown alga, Ecklonia cava, it exhibits antioxidant activity. | [in vivo]
Foliar application of Eckol (1 μM) significantly enhanced shoot and root length, shoot and root fresh and dry weight, leaf area and leaf number[2].
Eckol (50 or 100 μg/mouse; intradermal; once) reduces allergic inflammatory responses in the passive cutaneous anaphylaxis (PCA)-induced mice[3]. | Animal Model: | BALB/c mice (8 weeks old), IgE/BSA-induced passive cutaneous anaphylaxis (PCA) model[3] | | Dosage: | 50 or 100 μg/mouse | | Administration: | Intradermal injection, applied on mice ear 2 h prior to anaphylaxis induction | | Result: | Reduced allergic inflammatory responses. |
| [IC 50]
hMAO-A: 7.20 μM (IC50); hMAO-B: 83.44 μM (IC50); H1N1: 89.5 μM (IC50) |
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