| Identification | Back Directory | [Name]
Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(phenylmethoxy)-, (1'S,6'R)- | [CAS]
888042-13-5 | [Synonyms]
GF 15
Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(phenylmethoxy)-, (1'S,6'R)- | [Molecular Formula]
C23H21ClO6 | [MDL Number]
MFCD28963906 | [MOL File]
888042-13-5.mol | [Molecular Weight]
428.86 |
| Hazard Information | Back Directory | [Uses]
GF 15 is an inhibitor of centrosomal clustering during cell mitosis, with an EC50 value of 900 nM for inducing multipolar spindles. GF???15 is a derivative of griseofulvin that inhibits tubulin polymerization at concentrations above 25 μM. GF 15 inhibits tumor growth and significantly prolongs survival in mouse xenograft models of human colon cancer and multiple myeloma[1]. | [Biological Activity]
Cell permeable: yes''Reversible: yes | [in vivo]
Treatment of mouse xenograft models of human colon cancer and multiple myeloma with GF 15 results in tumor growth inhibition and significantly prolonged survival[1]. | [References]
[1] Raab MS, et al. GF-15, a novel inhibitor of centrosomal clustering, suppresses tumor cell growth in vitro and in vivo. Cancer Res. 2012 Oct 15;72(20):5374-85. DOI:10.1158/0008-5472.CAN-12-2026 |
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| Company Name: |
Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
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021-58955995 |
| Website: |
www.medchemexpress.com |
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