| Identification | Back Directory | [Name]
1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide | [CAS]
888719-03-7 | [Synonyms]
BMS-2
BMS2;BMS 2
N-(4-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydro
N-(4-(1H-PYRROLO[2,3-B]PYRIDIN-4-YLOXY)-3-FLUOROPHENYL)-1-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE
1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide
3-Pyridinecarboxamide, 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-
BMS-21-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide | [Molecular Formula]
C25H16F2N4O3 | [MDL Number]
MFCD16619360 | [MOL File]
888719-03-7.mol | [Molecular Weight]
458.42 |
| Chemical Properties | Back Directory | [Melting point ]
212-214℃ | [density ]
1.41 | [storage temp. ]
2-8°C | [solubility ]
ethanol: 1mg/mL
DMSO: 10mg/mL | [form ]
Solid | [pka]
10.72±0.70(Predicted) | [color ]
Off-white to light yellow | [InChI]
1S/C25H16F2N4O3/c26-15-3-6-17(7-4-15)31-13-1-2-19(25(31)33)24(32)30-16-5-8-22(20(27)14-16)34-21-10-12-29-23-18(21)9-11-28-23/h1-14H,(H,28,29)(H,30,32) | [InChIKey]
OBSFXHDOLBYWRJ-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Uses]
BMS-2 is a potent MET kinase inhibitor. | [in vivo]
MET kinase-IN-4 (Compound 2) (i.v., p.o.; 5, 10 mg/kg) possesses a favorable pharmacokinetic profile in mice[1].
MET kinase-IN-4 (p.o.; 6.25, 12.5, 25 and 50 mg/kg; once a day) demonstrates significant in vivo antitumor activity in the GTL-16 human gastric carcinoma xenograft model[1]. | Animal Model: | Mice[1] | | Dosage: | 5, 10 mg/kg | | Administration: | IV, PO | | Result: | Showed extensive extravascular distribution and a favorable half-life. |
| Animal Model: | Nude mice[1] | | Dosage: | 6.25, 12.5, 25 and 50 mg/kg | | Administration: | PO, once a day | | Result: | Showed antitumor activity in dose-dependet. |
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Lynnchem
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| Company Name: |
Novachemistry
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44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
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