| Identification | Back Directory | [Name]
(4-Methoxybenzyloxy)acetic acid | [CAS]
88920-24-5 | [Synonyms]
(4-METHOXYBENZYLOXY)ACETIC ACID
2-((4-Methoxybenzyl)oxy)acetic acid
Acetic acid, 2-[(4-methoxyphenyl)methoxy]- | [Molecular Formula]
C10H12O4 | [MDL Number]
MFCD01861881 | [MOL File]
88920-24-5.mol | [Molecular Weight]
196.2 |
| Chemical Properties | Back Directory | [Melting point ]
50.8-51.8 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4)) | [Boiling point ]
367.4±22.0 °C(Predicted) | [density ]
1.198±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
3.40±0.10(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Synthesis]
4-Methoxybenzyl alcohol (1 eq.) and bromoacetic acid (1.2 eq.) were dissolved in anhydrous tetrahydrofuran at 0 °C. Sodium hydride (60% w/w, mineral oil dispersion, 3 eq.) was added in three batches. The reaction mixture was stirred at 70 °C for 4 hours. After cooling to room temperature, water was added and the resulting mixture was washed with hexane. The aqueous phase was acidified to pH 2 with 1N hydrochloric acid and subsequently extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by silica gel column chromatography with hexane solution of 50% ethyl acetate as eluent gave (4-methoxybenzyloxy)acetic acid (0.51 g, 71% yield) as a colorless solid.1H NMR (500 MHz, CDCl3) δ 7.29 (m, 2H), 6.90 (m, 2H), 4.59 (s, 2H), 4.10 (s, 2H), 3.81 ( s, 3H). | [References]
[1] Bioorganic and medicinal chemistry letters, 2001, vol. 11, # 21, p. 2837 - 2841
[2] Synlett, 2012, vol. 23, # 19, p. 2845 - 2849
[3] Tetrahedron Letters, 2002, vol. 43, # 41, p. 7427 - 7429
[4] Patent: WO2014/144100, 2014, A2. Location in patent: Paragraph 00274
[5] Patent: WO2006/109729, 2006, A1. Location in patent: Page/Page column 138-139 |
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