| Identification | Back Directory | [Name]
9H-Furo[3,2-f][1]benzopyran-9-one, 7-(4-chlorophenyl)-2-[(2,3-dihydro-1H-indol-1-yl)carbonyl]-7,8-dihydro-1,7-dimethyl- | [CAS]
890808-56-7 | [Synonyms]
9H-Furo[3,2-f][1]benzopyran-9-one, 7-(4-chlorophenyl)-2-[(2,3-dihydro-1H-indol-1-yl)carbonyl]-7,8-dihydro-1,7-dimethyl- | [Molecular Formula]
C28H22ClNO4 | [MOL File]
890808-56-7.mol | [Molecular Weight]
471.93 |
| Chemical Properties | Back Directory | [Boiling point ]
661.6±55.0 °C(Predicted) | [density ]
1.353±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
0.90±0.20(Predicted) | [color ]
Light yellow to light brown |
| Hazard Information | Back Directory | [Uses]
M47 is a small molecule that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer[1]. | [in vivo]
M47 (5-1000 mg/kg; i.p.; daily, for 5 d; C57BL/6?J mice and p53 gene knockout C57BL/6?J mice) selectively reduces the half-life of CRY1 and is well tolerated with a good pharmacokinetic profile in vivo and enhances apoptosis[1]. | Animal Model: | C57BL/6?J mice and p53 gene knockout C57BL/6?J mice[1] | | Dosage: | 5, 50, 300 and 1000 mg/kg | | Administration: | intraperitoneal injection, daily, for 5 days | | Result: | Prolonged the life span of p53 gene knockout mice. |
| [References]
[1] Gul S, et, al. Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice. Nat Commun. 2022 Nov 8;13(1):6742. DOI:10.1038/s41467-022-34582-1 |
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