| Identification | Back Directory | [Name]
S3QEL 2 | [CAS]
890888-12-7 | [Synonyms]
S3QEL 2
1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(3,4-dimethylphenyl)-N,N-dipropyl- | [Molecular Formula]
C19H25N5 | [MOL File]
890888-12-7.mol | [Molecular Weight]
323.44 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: slightly soluble | [form ]
A crystalline solid | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Description]
S3QEL-2 is a cell-permeable, selective suppressor of electron leak from mitochondrial respiratory complex III, inhibiting site IIIQo superoxide production (IC50 = 1.7 μM) without altering normal bioenergetics function. It reduces production of H2O2 during oxidation of glutamate plus malate to 25% of the control level. S3QEL-2 also protects against ROS-induced cell stress in pancreatic β-cells and decreases HIF-1α induction in response to hypoxia. | [Uses]
S3QEL 2 supresses superoxide production by complex III in the mitochondria without affecting normal electron flux or cellular oxidative phosphorylation. | [References]
[1] ADAM L ORR. Suppressors of superoxide production from mitochondrial complex III[J]. Nature chemical biology, 2015, 11 11: 834-836. DOI: 10.1038/nchembio.1910 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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