| Identification | Back Directory | [Name]
Declopramide | [CAS]
891-60-1 | [Synonyms]
IMO-B
OXI-104
Declopramide
3-Chloroprocainamide
4-amino-3-chloro-N-(2-diethylaminoethyl)benzamide
4-azanyl-3-chloro-N-(2-diethylaminoethyl)benzamide
Benzamide, 4-amino-3-chloro-N-[2-(diethylamino)ethyl]- | [Molecular Formula]
C13H20ClN3O | [MDL Number]
MFCD02940854 | [MOL File]
891-60-1.mol | [Molecular Weight]
269.77 |
| Hazard Information | Back Directory | [Uses]
Declopramide (3-Chloroprocainamide) is an orally active antitumor agent, which inhibits proliferation of cancer cells HL60 and K562, and inhibits tumor growth of human brain astrocytoma (T24) in mouse model. Declopramide induces apoptosis, inhibits NF-κB through inhibition of IκBα degradation. Declopramide serves also as chemosensitizer in research[1][2][3]. | [References]
[1] Hua J, et al., Comparison of antitumor activity of declopramide (3-chloroprocainamide) and N-acetyl-declopramide. Anticancer Res. 1999 Jan-Feb;19(1A):285-90. PMID:10226556
[2] Hua J, et al., Pharmacokinetics and central nervous system toxicity of declopramide (3-chloroprocainamide) in rats and mice. Anticancer Drugs. 1999 Jan;10(1):79-88. DOI:10.1097/00001813-199901000-00010
[3] Lindgren H, et al., Differential usage of IkappaBalpha and IkappaBbeta in regulation of apoptosis versus gene expression. Biochem Biophys Res Commun. 2003 Jan 31;301(1):204-11. DOI:10.1016/s0006-291x(02)03012-7 |
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