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891075-67-5

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891075-67-5 Structure

891075-67-5 Structure
IdentificationBack Directory
[Name]

AKR1C3-IN-12
[CAS]

891075-67-5
[Synonyms]

AKR1C3-IN-12
[Molecular Formula]

C17H14N2O3
[MOL File]

891075-67-5.mol
[Molecular Weight]

294.31
Chemical PropertiesBack Directory
[density ]

1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

7.78±0.20(predicted)
Hazard InformationBack Directory
[Uses]

AKR1C3-IN-12 (compound 2j) is an aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 of 27 nM. AKR1C3-IN-12 enhances the efficacy of Gemcitabine and Cisplatin in bladder cancer[1].
[References]

[1] Rin Himura, et al. Inhibition of aldo-keto reductase 1C3 overcomes gemcitabine/cisplatin resistance in bladder cancer. Chem Biol Interact. 2024 Jan 25:388:110840. DOI:10.1016/j.cbi.2023.110840
891075-67-5 suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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