| Identification | Back Directory | [Name]
SR-4995 | [CAS]
891509-95-8 | [Synonyms]
SR-4995
Urea, N-butyl-N'-(10,11-dihydro-10-methyl-11-oxodibenzo[b,f][1,4]thiazepin-8-yl)- | [Molecular Formula]
C19H21N3O2S | [MOL File]
891509-95-8.mol | [Molecular Weight]
355.45 |
| Chemical Properties | Back Directory | [Boiling point ]
528.8±50.0 °C(Predicted) | [density ]
1.259±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
13.95±0.46(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
SR-4995 (CID 16016685) is a highly effective and selective ligand for α-β-hydrolase domain-containing 5 (ABHD5), facilitating the activation of adipose triglyceride lipase (ATGL) by displacing ABHD5 from its inhibitory regulators, perilipin-1 (PLIN1) and PLIN5. It directly interacts with ABHD5, inhibiting its association with PLIN1, and promotes lipolysis in adipocytes and muscle tissues while circumventing PKA-dependent signaling pathways. | [Biological Activity]
SR-4995 is a potent and selective ligand of α-β-hydrolase domain containing 5 (ABHD5) th at activates adipose triglyceride lipase (ATGL) by dissociating ABHD5 from its inhibitory regulatorperilipin-1 (PLIN1) and PLIN5. SR-4995 directly binds to ABHD5 and prevents ABHD5 to PLIN1. SR-4995 induces lipolysis in adipocytes and muscleavoiding PKA-dependent signaling. |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|