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UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research[1]. | [in vivo]
UT-B-IN-1 (300 μg; i.p., once) increases urine output and reduces urine osmolality in mice with free access to water and food[1]. | Animal Model: | Male mice (wild-type or UT-B knockout)[1] | | Dosage: | 300 μg | | Administration: | Intraperitoneal injection, 300 μg, once | | Result: | Reduced urine osmolality and urea concentration in wild-type mice with V2-receptor agonist dDAVP injection. Increased urine volume and reduced urine osmolality and urea concentration in mice with free access to food and water but without dDAVP. |
| [References]
[1] Yao C, et al. Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration. J Am Soc Nephrol. 2012 Jul;23(7):1210-20. DOI:10.1681/ASN.2011070751 |
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