| Identification | Back Directory | [Name]
PHENYL (3-SULFOPROPYL) ETHER, POTASSIUM SALT | [CAS]
89574-82-3 | [Synonyms]
PSP
PSPN
P14.5
UK114
BPIFA2
SPLUNC2
C20orf70
bA49G10.1
Persephin from mouse
Phenyl-3-sulfopropyl ether
3-phenoxypropane-1-sulfonate
Pore membrane protein of 121 kDa
potassium 3-phenoxypropanesulphonate
PHENYL (3-SULFOPROPYL) ETHER, POTASSIUM SALT
Nuclear envelope pore membrane protein POM 121
3-Phenoxy-1-propanesulfonic acid potassium salt
Monoclonal Anti-REG1A antibody produced in mouse
Monoclonal Anti-BPIFA2 antibody produced in mouse
Anti-POM121, C-Terminal antibody produced in rabbit | [EINECS(EC#)]
289-508-3 | [Molecular Formula]
C9H13KO4S | [MDL Number]
MFCD00801051 | [MOL File]
89574-82-3.mol | [Molecular Weight]
256.36 |
| Hazard Information | Back Directory | [Uses]
Persephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF (glial cell line-derived neurotrophic factor), Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFRα (α1-α4) receptors. The GFRα4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dopaminergic neurons and motor neurons after sciatic nerve axotomy, and like GNDF, promotes ureteric bud branching. Recombinant murine Persephin is a disulfide-linked homodimer, composed of two 10.3 kDa polypeptide chains (96 total amino acid residues). Each chain contains seven conserved cysteine residues, one of which (Cys 63) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration. Persephin is one of the GDNF family ligands and belongs to transforming growth factor β (TGF-β) superfamily. | [Biological Activity]
In contrast to GDNF (glial cell line-derived neurotrophic factor) and neurturinpersephin does not support survival of peripheral neurons. Persephin induces differentiation of mesencephalic dopaminergic neurons. | [References]
[1] XIAOJIAO DI . Monitoring hydrogen polysulfide during ferroptosis with a two-photon fluorescent probe[J]. Talanta, 2021, 232: Article 122467. DOI: 10.1016/j.talanta.2021.122467 |
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