| Chemical Properties | Back Directory | [Boiling point ]
484.823±45.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.088±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
13.941±0.46(predicted) |
| Hazard Information | Back Directory | [Description]
GSK931145 is a newly developed positron emission tomography (PET) radioligand suitable for quantifying glycine transporter (GlyT1) availability in the living brain. | [Uses]
GSK931145 is a glycine transporter 1 (GlyT1) inhibitor with anti-epileptic activity. GSK931145 exhibits a low minimum effective dose in the maximum electrical stimulation threshold test, indicating that it has a significant anti-epileptic effect. GSK931145 is also suitable as a positron emission tomography (PET) radioligand for quantifying the availability of glycine transporters in the living brain[1]. | [References]
[1] Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test |
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