| Hazard Information | Back Directory | [Description]
A 55453 is a radiated ionophore used as a high-affinity alpha 1-adrenergic receptor probe. It is a ligand that binds reversibly to rat hepatic plasma membranes with high affinity; thus it can be useful for the molecular characterization of alpha 1-adrenergic receptors in tissues. | [Uses]
A55453 is a prazosin analogue and a potent α1-adrenergic antagonist. 125I-A55453 is a high-affinity alpha 1-adrenergic receptor probe[1]. | [References]
[1] Dickinson KE, et al. Photoaffinity cross-linking of a radioiodinated probe, 125I-A55453, into alpha 1-adrenergic receptors. Mol Pharmacol. 1984;26(2):187-195. PMID:6090880 |
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