| Identification | Back Directory | [Name]
Benzenepropanamide, N-[3-(6-methyl-1H-benzimidazol-2-yl)phenyl]- | [CAS]
897799-81-4 | [Synonyms]
MMP2-IN-3
Benzenepropanamide, N-[3-(6-methyl-1H-benzimidazol-2-yl)phenyl]- | [Molecular Formula]
C23H21N3O | [MOL File]
897799-81-4.mol | [Molecular Weight]
355.43 |
| Hazard Information | Back Directory | [Uses]
MMP2-IN-3 (compound 2) is a potent MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 31 μM. MMP2-IN-3 also shows inhibitory activity against MMP-9 and MMP-8, with IC50 values of 26.6, and 32 μM, respectively[1]. | [IC 50]
MMP-9: 26.6 ± 2.3 μM (IC50); MMP-2: 31 ± 5 μM (IC50); MMP-8: 32 ± 4 μM (IC50); MMP-13: >100 μM (IC50) | [References]
[1] Laghezza A, et al. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. Bioorg Med Chem. 2020 Feb 1;28(3):115257. DOI:10.1016/j.bmc.2019.115257 |
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