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898537-18-3

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898537-18-3 Structure

898537-18-3 Structure
IdentificationBack Directory
[Name]

D-Glucitol, 1,5-dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)Methyl]-2-Methoxy-4-Methylphenyl]-, (1S)-
[CAS]

898537-18-3
[Synonyms]

TS-71
TS 071
(Lusefi)
Luseogliflozin
TS 071; TS071; TS-71
Luseogliflozin USP/EP/BP
(1S)-1,5-Dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)methyl]-2-methoxy-4-methylphenyl]-D-glucitol
D-Glucitol, 1,5-dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)Methyl]-2-Methoxy-4-Methylphenyl]-, (1S)-
(2S,3R,4R,5S,6R)-2-[5-[(4-ethoxyphenyl)methyl]-2-methoxy-4-methylphenyl]-6-(hydroxymethyl)thiane-3,4,5-triol
D-Glucitol, 1,5-dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)Methyl]-2-Methoxy-4-Methylphenyl]-, (1S)- USP/EP/BP
Luseogliflozin,D-Glucitol, 1,5-dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)Methyl]-2-Methoxy-4-Methylphenyl]-, (1S)-
[Molecular Formula]

C23H30O6S
[MDL Number]

MFCD18251435
[MOL File]

898537-18-3.mol
[Molecular Weight]

434.56
Chemical PropertiesBack Directory
[Melting point ]

155.0-157.0℃
[Boiling point ]

624.5±55.0 °C(Predicted)
[density ]

1.278±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

13.25±0.70(Predicted)
[color ]

White to off-white
[InChIKey]

WHSOLWOTCHFFBK-ZQGJOIPISA-N
[SMILES]

[C@H]1(S[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C1=CC(CC2=CC=C(OCC)C=C2)=C(C)C=C1OC
Hazard InformationBack Directory
[Uses]

Luseogliflozin is used n biological studies as a potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycemic activity.
[Definition]

ChEBI: Luseogliflozin is a diarylmethane.
[in vivo]

Luseogliflozin (10 mg/kg, oral, 7 days) improves hyperglycemia and promotes β-cell proliferation in mice[2].

Animal Model:C57BL/6J male mice induced by OSI-906[2]
Dosage:10 mg/kg/daily, 7 days
Administration:Oral
Result:Inhibited SGLT2 and significantly improved hyperglycemia in mice, but did not improve hyperinsulinemia.Had no effect on hepatic steatosis and adipose tissue atrophy, and improved the quality and proliferation of β cells.
[IC 50]

SGLT2: 2.26 nM (IC50); SGLT1: 3990 nM (IC50)
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