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Tiflucarbine (BAY-P 4495) is a tetrahydrothieno-7-carboline derivative. Tiflucarbine is a potent antidepressant agent that binds at central serotonin (5-HT) binding sites. Tiflucarbine is a nonselective 5-HT (5-HT1 and 5-HT2) agonist[1][2]. | [References]
[1] Schmidt BH, et al. Evidence for a specific recognition site for tiflucarbine on calmodulin. Eur J Pharmacol. 1990 Dec 15;189(6):411-8. DOI:10.1016/0922-4106(90)90039-z
[2] Glennon RA, et al. Stimulus properties of tiflucarbine: a novel antidepressant agent. Pharmacol Biochem Behav. 1990 Dec;37(4):769-71. DOI:10.1016/0091-3057(90)90561-u |
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