| Identification | Back Directory | [Name]
4-acetylpiperidinium chloride | [CAS]
89895-06-7 | [Synonyms]
4-acetylpiperidinium chloride
1-(Piperidin-4-yl)ethanone, HCl
4-Acetylpiperidine hydrochloride
4-Acetylpiperidine hydrochloride,98%
1-(4-Piperidyl)ethanone Hydrochloride
1-(4-Piperidinyl)ethanone hydrochloride
1-(Piperidin-4-yl)ethanone hydrochloride
Ethanone, 1-(4-piperidinyl)-, hydrochloride
Ethanone,1-(4-piperidinyl)-, hydrochloride (1:1)
ETHANONE,1-(4-PIPERIDINYL)-,HYDROCHLORIE (1 : 1) | [EINECS(EC#)]
289-528-2 | [Molecular Formula]
C7H14ClNO | [MDL Number]
MFCD00044810 | [MOL File]
89895-06-7.mol | [Molecular Weight]
163.645 |
| Chemical Properties | Back Directory | [Melting point ]
151-158°C | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
1-(4-Piperidinyl)ethanone is used in the synthesis of oral antagonists for the treatment of rheumatoid arthritis. Also used in the synthesis of p38 mitogen activated protein kinase. | [Synthesis]
General procedure for the synthesis of 1-(4-piperidinyl)ethanone hydrochloride from 1-N-BOC-4-acetylpiperidine: To an anhydrous dichloromethane (5 mL) solution of 1-N-BOC-4-acetylpiperidine (350 mg, 1.54 mmol) was slowly added a dioxane solution (2 mL) of 4 M HCl at 0 °C. The reaction mixture was stirred continuously at 0°C for 2 hours. Upon completion of the reaction, the mixture was concentrated by rotary evaporator to afford 1-(4-piperidinyl)ethanone hydrochloride (260 mg, 100% yield) as a white solid, which could be used directly in the subsequent reaction without further purification. | [References]
[1] Patent: WO2013/96744, 2013, A1. Location in patent: Page/Page column 192
[2] Patent: EP3255042, 2017, A2. Location in patent: Paragraph 0209; 0213 |
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