| Identification | Back Directory | [Name]
6-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE | [CAS]
89976-75-0 | [Synonyms]
6-amino-4H-1,4-benzoxazin-3-one
6-AMINO-4H-BENZO[1,4]OXAZIN-3-ONE
6-Amino-2H-1,4-benzoxin-3(4H)-one
6-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE
2H-1,4-benzoxazin-3(4H)-one, 6-amino-
6-Amino-2H-1,4-benzoxazin-3(4H)-one 97%
6-amino-2,4-dihydro-1,4-benzoxazin-3-one
6-Amino-3-oxo-3,4-dihydrobenzo[1,4]oxazine
6-AMino-3,4-dihydro-2H-1,4-benzoxazin-3-one
6-Amino-3,4-dihydro-3-oxo-2H-1,4-benzoxazine
6-amino-2H-1,4-benzoxazin-3(4H)-one(SALTDATA: FREE) | [Molecular Formula]
C8H8N2O2 | [MDL Number]
MFCD03425742 | [MOL File]
89976-75-0.mol | [Molecular Weight]
164.16 |
| Chemical Properties | Back Directory | [Melting point ]
266-268°C | [density ]
1.344 | [storage temp. ]
2-8°C | [form ]
solid | [color ]
Pale brown | [InChI]
1S/C8H8N2O2/c9-5-1-2-7-6(3-5)10-8(11)4-12-7/h1-3H,4,9H2,(H,10,11) | [InChIKey]
GEPGYMHEMLZMBC-UHFFFAOYSA-N | [SMILES]
Nc1ccc2OCC(=O)Nc2c1 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 6-amino-2H-1,4-benzomorpholin-3(4H)-one from 6-nitro-2H-1,4-benzoxazin-3(4H)-one: to a solution of 6-nitro-2H-1,4-benzoxazin-3(4H)-one (2.97 g, 15.00 mmol) in methanol (50 mL) was added 10% palladium/carbon catalyst (0.30 g). The reaction mixture was stirred under hydrogen atmosphere for 16 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford 6-amino-2H-1,4-benzomorpholin-3(4H)-one (2.36 g, 95% yield) as a brown solid. Mass spectrometry (MS) analysis showed a molecular ion peak of 165 (M + H). | [References]
[1] ChemCatChem, 2014, vol. 6, # 11, p. 3153 - 3159
[2] Patent: WO2018/19252, 2018, A1. Location in patent: Page/Page column 37
[3] ChemSusChem, 2017, vol. 10, # 15, p. 3035 - 3039
[4] Journal of Medicinal Chemistry, 2005, vol. 48, # 1, p. 71 - 90
[5] Patent: US2009/298819, 2009, A1. Location in patent: Page/Page column 16; 22 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|