| Identification | Back Directory | [Name]
1-BroMo-4-Methoxy-2-Methyl-5-nitrobenzene | [CAS]
89978-56-3 | [Synonyms]
4-Bromo-5-methyl-2-nitroanisole
4-Bromo-5-methyl-2-nitroanisole 95+%
1-BroMo-4-Methoxy-2-Methyl-5-nitrobenzene
Benzene, 1-bromo-4-methoxy-2-methyl-5-nitro- | [Molecular Formula]
C8H8BrNO3 | [MDL Number]
MFCD23703052 | [MOL File]
89978-56-3.mol | [Molecular Weight]
246.06 |
| Chemical Properties | Back Directory | [Melting point ]
110-111 °C | [Boiling point ]
336.9±37.0 °C(Predicted) | [density ]
1.559±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [Appearance]
White to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 1-bromo-4-methoxy-2-methyl-5-nitrobenzene from 2-bromo-5-methoxytoluene: 2-bromo-5-methoxytoluene (2.5 g, 12.5 mmol) was suspended in dichloroethane (DCE, 20 mL) at room temperature, followed by the addition of bismuth nitrate pentahydrate (7.28 g, 15 mmol). The reaction mixture was stirred at 80 °C overnight. After completion of the reaction, the mixture was cooled to room temperature and filtered to remove insoluble material. The filtrate was concentrated and purified by silica gel column chromatography (eluent ratio ethyl acetate:petroleum ether = 1:10) to afford 1-bromo-4-methoxy-2-methyl-5-nitrobenzene (152) as a light yellow solid (119 g, 39% yield). Mass spectral analysis showed [M + H]+ m/z 246. | [References]
[1] Synthesis (Germany), 2017, vol. 49, # 12, p. 2768 - 2774
[2] Patent: WO2017/176812, 2017, A1. Location in patent: Paragraph 0416
[3] Patent: US2013/116229, 2013, A1. Location in patent: Paragraph 1011 |
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