| Identification | Back Directory | [Name]
Urea, N-(3-chloro-4-methylphenyl)-N'-1H-indol-3-yl- | [CAS]
899947-07-0 | [Synonyms]
STING-IN-7
Urea, N-(3-chloro-4-methylphenyl)-N'-1H-indol-3-yl- | [Molecular Formula]
C16H14ClN3O | [MOL File]
899947-07-0.mol | [Molecular Weight]
299.75 |
| Hazard Information | Back Directory | [Uses]
STING-IN-7 (compound 21) is a potent STING inhibitor with an IC50 of 11.5 nM. STING-IN-7 inhibits the phosphorylation of STING and interferon regulatory factor 3 (IRF3)[1]. | [References]
[1] Po-Wei Chang, et al. Analysis of structure-activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors. Bioorg Med Chem. 2023 Oct 14:95:117502. DOI:10.1016/j.bmc.2023.117502 |
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