| Identification | Back Directory | [Name]
PROTAMINE SULFATE | [CAS]
9009-65-8 | [Synonyms]
fluxema
usafd-4
SALMINE
dilangio
vasorelax
Ccris 8521
angiociclan
SALMINE SULFATE
Protamne sulfate
CLUPEINE SULFATE
Protamin sulfate
Protamina solfato
Protemine Sulfate
ProtaMine sulfates
Protamines,sulfates
PROTAMINE SULFATE SALT
Protamina solfato [dcit]
PROTAMINE SULFATE SALMON
PROTAMINE SULFATE HERRING
Protamine Sulfate, USP, EP
Protamine Sulfate (1578612)
Protamine Sulfate (2.69 mg)
Protamine sulfate (Y0002179)
Protamine sulfate, from milt
ProtamineSulphateExSalmonRoe
PROTAMINE SULFATE (EX SALMON)
PROTAMINE SULFATE, SALMON MILT
Protamine sulfate 1g [9009-65-8]
Protamine Sulfate From Salmon Sperm, Molecular biology
Protamine sulfate, Salmine sulfate from salmon sperm | [EINECS(EC#)]
232-726-0 | [Molecular Formula]
H2O4S | [MDL Number]
MFCD00132091 |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, hygroscopic powder. | [storage temp. ]
+2C to +8C | [solubility ]
H2O: 10 mg/mL
| [form ]
amorphous powder
| [color ]
white
| [Water Solubility ]
It is sparingly soluble in water. | [Sensitive ]
Hygroscopic | [Cosmetics Ingredients Functions]
SKIN CONDITIONING | [EPA Substance Registry System]
Protamines, sulfates (9009-65-8) |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, hygroscopic powder. | [Uses]
Antidote (to heparin). | [in vivo]
Protamine sulfate can be used in animal modeling to create cystitis models[5].
Induction of cystitis model[5] Background
The presence and activity of protamine sulfate may trigger the activation and inflammatory response of the host immune system. These immune responses can lead to the infiltration of inflammatory cells and the production of inflammatory mediators, such as cytokines and interleukins, which can lead to cystitis.
Specific Modeling Methods
Rat: Sprague-Dawley ? female &bull
Administration: 10 mg/mL irrigation in the urinary bladder ? once
Note
(1) 10 mg/ml protamine sulfate was injected into the rat bladder, and 2 mg/ml LPS was injected 30 minutes later
(2) 5 days later, the experimental animals were put to death under anesthesia, and the bladder was removed for observation.
Modeling Indicators Physiological indicators: The turbidity, urine volume and the number of red blood cells in the urine of rats were detected.
Molecular changes: The levels of biomarkers IL-6, TNF-α and NF-κB in bladder tissues were detected.
Histological analysis: Hematoxylin and eosin staining were used to detect the number of mast cells in the bladder of rats.
Correlated Product(s): LPS (HY-D1056) Opposite Product(s): / |
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| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|