| Identification | Back Directory | [Name]
LpxH-IN-AZ1 | [CAS]
901260-40-0 | [Synonyms]
LpxH-IN-AZ1
LpxHINAZ1,LpxH-IN-AZ-1,LpxH IN AZ1
Ethanone, 1-[2,3-dihydro-5-[[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]sulfonyl]-1H-indol-1-yl]-
1-[5-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1H-indol-1-yl]ethan-1-one | [Molecular Formula]
C21H22F3N3O3S | [MDL Number]
MFCD14748598 | [MOL File]
901260-40-0.mol | [Molecular Weight]
453.48 |
| Chemical Properties | Back Directory | [Boiling point ]
659.1±65.0 °C(Predicted) | [density ]
1.395±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.46±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
LpxH-IN-AZ1, a sulfonyl piperazine compound, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. LpxH-IN-AZ1 is a potent inhibitor of Klebsiella pneumoniae LpxH with IC50 of 0.36 μM [1]. | [References]
[1] Cho J, et al. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4109-4116. DOI:10.1073/pnas.1912876117 |
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