| Identification | Back Directory | [Name]
Pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidine-3-propanamide, 2,4-dimethyl-N-[3-(methylthio)phenyl]- | [CAS]
902614-04-4 | [Synonyms]
PANKi
Pantothenate Kinase Inhibitor
Pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidine-3-propanamide, 2,4-dimethyl-N-[3-(methylthio)phenyl]-
3-(2,4-Dimethylpyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-(methylthio)phenyl)propanamide
3-{4,6-dimethyl-3,7,8,10-tetraazatricyclo[7.4.0.0,2,7]trideca-1,3,5,8,10,12-hexaen-5-yl}-N-[3-(methylsulfanyl)phenyl]propanamide | [Molecular Formula]
C21H21N5OS | [MOL File]
902614-04-4.mol | [Molecular Weight]
391.49 |
| Chemical Properties | Back Directory | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 1 mg/ml,DMSO: 1 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.25 mg/ml | [form ]
A crystalline solid | [pka]
13.98±0.70(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Uses]
Pantothenate kinase-IN-2 is a potent Pantothenate kinase 1/3 (PanK1/3) inhibitor with an IC50 of 0.14 μM and 0.36 μM. Pantothenate kinase-IN-2 is a promising agent for PKAN (PanK-associated neurodegeneration) and diabetes research[1]. | [Biological Activity]
Cell permeable: yes''Primary Target
pantothenate kinase''Reversible: yes''Target IC50: 7092 and 25 nM for PanK1&beta | [storage]
Store at -20°C | [References]
[1] Lalit Kumar Sharma, et al. A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases. J Med Chem. 2015 Feb 12;58(3):1563-8. DOI:10.1021/jm501585q |
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| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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