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903206-81-5

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903206-81-5 Structure

903206-81-5 Structure
IdentificationBack Directory
[Name]

2-(1H-benzimidazol-2-ylsulfanyl)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethanone
[CAS]

903206-81-5
[Synonyms]

Tyrosinase-IN-31
Ethanone, 2-(1H-benzimidazol-2-ylthio)-1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-
2-(1H-benzimidazol-2-ylsulfanyl)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethanone
[Molecular Formula]

C20H21N3O3S
[MOL File]

903206-81-5.mol
[Molecular Weight]

383.46
Chemical PropertiesBack Directory
[Boiling point ]

634.4±65.0 °C(Predicted)
[density ]

1.36±0.1 g/cm3(Predicted)
[pka]

10.63±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

Tyrosinase-IN-31 (compound 2-06) is a central-targeting tyrosinase inhibitor (tyrosinase: monophenolase IC50=70.44 μM, diphenolase IC50=1.89 μM). Tyrosinase-IN-31 can inhibit the tyrosinase and melanogenesis. Tyrosinase-IN-31 can penetrate the BBB and enter the central nervous system (CNS). Tyrosinase-IN-31 shows neuroprotective effects and Parkinsonism behavior improving function[1].
[References]

[1] Qi S, et al. A new strategy for the treatment of Parkinson's disease: Discovery and bio-evaluation of the first central-targeting tyrosinase inhibitor. Bioorg Chem. 2024 Sep;150:107612. DOI:10.1016/j.bioorg.2024.107612
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