ChemicalBook--->CAS DataBase List--->90322-32-0

90322-32-0

90322-32-0 Structure

90322-32-0 Structure
IdentificationBack Directory
[Name]

2-METHYL-1,3-BENZOXAZOLE-5-CARBOXYLIC ACID
[CAS]

90322-32-0
[Synonyms]

OTAVA-BB 1136981
2-Methyl-5-Benzoxazolecarboxylic acid
2-Methylbenzoxazole-5-carboxylic Acid
5-Benzoxazolecarboxylic acid, 2-Methyl-
2-Methyl-benzooxazole-6-carboxylic acid
2-METHYL-BENZOOXAZOLE-5-CARBOXYLIC ACID
2-Methylbenzo[d]oxazole-5-carboxylic acid
2-METHYL-1,3-BENZOXAZOLE-5-CARBOXYLIC ACID
[Molecular Formula]

C9H7NO3
[MDL Number]

MFCD09759125
[MOL File]

90322-32-0.mol
[Molecular Weight]

177.16
Chemical PropertiesBack Directory
[Melting point ]

186-188℃
[Boiling point ]

353.5±15.0 °C(Predicted)
[density ]

1.38
[storage temp. ]

Sealed in dry,Room Temperature
[pka]

3.53±0.30(Predicted)
[Appearance]

Light brown to off-white Solid
Questions And AnswerBack Directory
[Uses]

2-Methyl-5-benzoxazole carboxylic acid is used as an organic synthesis intermediate for the preparation of other active substances.
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H335-H319
[Precautionary statements ]

P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
[HS Code ]

2934999090
Spectrum DetailBack Directory
[Spectrum Detail]

2-METHYL-1,3-BENZOXAZOLE-5-CARBOXYLIC ACID(90322-32-0)1HNMR
Hazard InformationBack Directory
[Synthesis]

METHYL 2-METHYL-1,3-BENZOXAZOLE-5-CARBOXYLATE

136663-21-3

2-METHYL-1,3-BENZOXAZOLE-5-CARBOXYLIC ACID

90322-32-0

). The reaction mixture was stirred at 25 °C for 3 hours. Upon completion of the reaction, the mixture was acidified to pH < 7 with dilute hydrochloric acid and a white solid was precipitated. The solid product was collected by filtration, washed with deionized water and subsequently dried under vacuum. Finally, the crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=1:1, v/v) to afford the target compound 2-methyl-5-benzoxazolecarboxylic acid (0.30 g, 65% yield) as a white solid.

[References]

[1] Patent: WO2016/100184, 2016, A1. Location in patent: Paragraph 00321-00322
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