| Identification | Back Directory | [Name]
3,9-Diazabicyclo[3.3.1]non-6-ene-6-carboxaMide, N-cyclopropyl-7-[4-[2-(2,6-dichloro-4-Methylphenoxy)ethoxy]phenyl]-N-[(2,3-diMethylphenyl)Methyl]-, (1R,5S)- | [CAS]
903579-36-2 | [Synonyms]
(1R,5S)-N-cyclopropyl-7-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)-N-(2,3-dimethylbenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide
(1R,5S)-N-cyclopropyl-7-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]-N-[(2,3-dimethylphenyl)methyl]-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide
3,9-Diazabicyclo[3.3.1]non-6-ene-6-carboxaMide, N-cyclopropyl-7-[4-[2-(2,6-dichloro-4-Methylphenoxy)ethoxy]phenyl]-N-[(2,3-diMethylphenyl)Methyl]-, (1R,5S)- | [Molecular Formula]
C35H39Cl2N3O3 | [MDL Number]
MFCD18642604 | [MOL File]
903579-36-2.mol | [Molecular Weight]
620.608 |
| Hazard Information | Back Directory | [Uses]
MK-8141 (ACT-077825) is a renin inhibitor that significantly increases levels of immunoreactive renin (ir-AR) by sevenfold but does not result in sustained reductions in blood renin activity (PRA). This study evaluated the antihypertensive efficacy of MK-8141 in hypertensive disease. Despite its effects on ir-AR, MK-8141 (ACT-077825) did not produce significant blood pressure-lowering effects in the absence of sustained PRA inhibition. | [References]
[1] Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors
J. Med. Chem., 2009, 52 (12), pp 3689-3702 DOI:10.1016/j.jash.2010.06.006 |
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