| Identification | Back Directory | [Name]
PRX 07034 | [CAS]
903580-39-2 | [Synonyms]
PRX 07034
N-[1-(5-chloro-2,3-dimethoxyphenyl)ethyl]-2-methylsulfonyl-5-piperazin-1-ylaniline:hydrochloride
Benzenemethanamine, 5-chloro-2,3-dimethoxy-α-methyl-N-[2-(methylsulfonyl)-5-(1-piperazinyl)phenyl]-, hydrochloride
Benzenemethanamine, 5-chloro-2,3-dimethoxy-α-methyl-N-[2-(methylsulfonyl)-5-(1-piperazinyl)phenyl]-, monohydrochloride | [Molecular Formula]
C21H28ClN3O4S.ClH | [MDL Number]
MFCD25976674 | [MOL File]
903580-39-2.mol | [Molecular Weight]
490.45 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
White to off-white | [InChI]
InChI=1S/C21H28ClN3O4S.ClH/c1-14(17-11-15(22)12-19(28-2)21(17)29-3)24-18-13-16(25-9-7-23-8-10-25)5-6-20(18)30(4,26)27;/h5-6,11-14,23-24H,7-10H2,1-4H3;1H | [InChIKey]
PILCQJJJAFRKHO-UHFFFAOYSA-N | [SMILES]
N(C1C=C(N2CCNCC2)C=CC=1S(=O)(=O)C)C(C1C=C(C=C(C=1OC)OC)Cl)C.Cl |
| Hazard Information | Back Directory | [Uses]
PRX-07034 hydrochloride is a highly selective and potent 5-HT6 receptor antagonist with a Ki= 4-8 nM and an IC50 of 19 nM. PRX-07034 can be used for the research of enhancing working memory and cognitive flexibility[1]. | [in vivo]
PRX-07034 (0.1, 1, or 3 mg/kg; i.p.; 30 min prior to delayed spontaneous alternation testing) selectively enhances a switch to a place discrimination[1]. | Animal Model: | Male Long-Evans rats weighing approximately 350 g[1] | | Dosage: | 0.1, 1, or 3 mg/kg | | Administration: | Injected intraperitoneal | | Result: | 1 and 3 mg/kg (but not 0.1 mg/kg) significantly enhanced delayed spontaneous alternation. The drug at 1 and 3 mg/kg also enhanced switching between a place and response strategy, but did not affect initial learning of either a place or response discrimination. |
| [IC 50]
5-HT6 Receptor: 4-8 nM (Ki); 5-HT6 Receptor: 19 nM (IC50); 5-HT1B Receptor: 260 nM (Ki); 5-HT1A Receptor: 420 nM (Ki); 5-HT1D Receptor: 2.8 μM (Ki); 5-HT2A Receptor: 2.5 μM (IC50); 5-HT2B Receptor: 2.5 μM (IC50); 5-HT2C Receptor: 3.7 μM (IC50); Dopamine D3 Receptor: 71 nM (Ki); Opioid μ Receptor: 0.45 μM (Ki); Histamine H2 Receptor: 0.64 μM (Ki) | [storage]
Store at -20°C | [References]
[1] Eric G Mohler, et al. The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats. Psychopharmacology (Berl). 2012 Apr;220(4):687-96. DOI:10.1007/s00213-011-2518-7 |
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