| Identification | Back Directory | [Name]
Thiosulfuric acid (H2S2O3), S-[2-[[(6,6-dimethylbicyclo[3.1.1]hept-2-yl)methyl]amino]-2-iminoethyl] ester | [CAS]
90379-42-3 | [Synonyms]
Thiosulfuric acid (H2S2O3), S-[2-[[(6,6-dimethylbicyclo[3.1.1]hept-2-yl)methyl]amino]-2-iminoethyl] ester | [Molecular Formula]
C12H22N2O3S2 | [MOL File]
90379-42-3.mol | [Molecular Weight]
306.45 |
| Hazard Information | Back Directory | [Uses]
NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations[1]. | [References]
[1] Rakesh Chatrikhi, et al. A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex. Cell Chem Biol. 2021 Aug 19;28(8):1145-1157.e6. DOI:10.1016/j.chembiol.2021.02.007
[2] Riccardo Rozza, et al. Assessing the Binding Mode of a Splicing Modulator Stimulating Pre-mRNA Binding to the Plastic U2AF2 Splicing Factor. J Chem Inf Model. 2023 Dec 11;63(23):7508-7517. DOI:10.1021/acs.jcim.3c01204 |
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