| Identification | Back Directory | [Name]
PECTIC ACID | [CAS]
9046-40-6 | [Synonyms]
PECTIC ACID
PECTIC ACID tech
Methyl protopectin
PECTIC ACID FROM APPLES
pectin, esterified from citrus fruit
PECTIN, ESTERIFIED, DEGREE OF*ESTERI
Pectic acid from apple, Poly-D-galacturonic acid | [Molecular Formula]
[C6H8O6]n | [MDL Number]
MFCD00132862 | [MOL File]
9046-40-6.mol | [Molecular Weight]
546.388 |
| Chemical Properties | Back Directory | [form ]
powder | [biological source]
synthetic | [Uses]
Those pectic substances that are essentially void of methoxyl groups and have carboxyl groups only. They have varying degrees of neutralization. The divalent salts are slightly soluble in water and must be converted to the sodium or potassium forms for dissolution. It gels in the presence of calcium or other divalent cations. |
| Hazard Information | Back Directory | [Chemical Properties]
powder pH (1%) 4.2-5 | [Uses]
forms strong resilient films and fibers | [in vivo]
Pectic acid (25 and 100 mg/kg, oral gavage) increases colon length, downregulates disease activity index, histopathological score and proinflammatory cytokine levels in Ulcerative colitis (UC) mice[3].
Pectic acid (6.25 and 12.5 mg/kg, intravenous injection) rescues the reduction in colon length in UC mice[3].
| Animal Model: | Ulcerative colitis (UC) mice[3] | | Dosage: | 25, 100 mg/kg | | Administration: | Oral gavage | | Result: | Exhibited the longest colon, lowest DAI, and minimum histopathological score.
Decreased the proinflammatory cytokines in the colonic tissue of UC mice.
|
| Animal Model: | Ulcerative colitis (UC) mice[3] | | Dosage: | 6.25, 12.5 mg/kg | | Administration: | Intravenous injection | | Result: | Decreased the spleen and thymus index.
Restored the Th17/Treg balance in the spleen and lamina propria of UC mice.
Improved the gut microbiota composition.
|
| [IC 50]
Human Endogenous Metabolite | [Purification Methods]
Citrus pectic acid (500g) is refluxed for 18hours with 1.5L of 70% EtOH, and the suspension is filtered hot. The residue is washed with hot 70% EtOH and finally with ether. It is dried in a current of air, ground and dried for 18hours at 80o under vacuum. [Morell & Link J Biol Chem 100 385 1933.] It can be further purified by dispersing it in water and adding just enough dilute NaOH to dissolve the pectic acid, then passing the solution through columns of cation-and anion-exchange resins [Williams & Johnson Ind Eng Chem (Anal Ed) 16 23 1944], and precipitating with two volumes of 95% EtOH containing 0.01% HCl. The precipitate is worked with 95% EtOH, then Et2O, dried and ground. [Rees & Walsh Angew Chem Int Edn 16 214 1977, Rees Adv Carbohydr Chem 24 267 1969.] |
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